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- W2382374000 abstract "1 report the mid-term and long-term outcomes of the use of human embryonic stem-cell (hESC)-derived retinal pigment epithelial cells for the treatment of dry atrophic age-related macular degeneration and Stargardt's macular dystrophy, the leading causes of adult and juvenile blindness in the developed world. Both eye diseases involve a disruption of the retinal pigment epithelium, a layer of cells behind the retina that helps to maintain photoreceptors and preserve the blood-retina barrier. In the studies, hESC were diff erentiated into retinal pigment epithelium cells, and these cells were injected into the subretinal space in the eye with the worst vision in 18 patients— nine with atrophic age-related macular degeneration and nine with Stargardt's macular dystrophy. The median follow-up was 22 months. Visual acuity improved in ten eyes, remained the same or improved in seven eyes, and decreased by more than ten letters in one eye. The untreated fellow eyes did not show similar improvement. The safety and visual acuity outcomes in the 18 patients further validate the earlier fi ndings reported for the fi rst patient in two studies in 2012. 2,3" @default.
- W2382374000 created "2016-06-24" @default.
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- W2382374000 date "2014-01-01" @default.
- W2382374000 modified "2023-09-27" @default.
- W2382374000 title "Human stem cell-derived retinal cells for macular diseases" @default.
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