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- W2382384811 abstract "Objective To explore the characterizations of natural killer(NK) cells in rheumatoid arthritis(RA) and potential roles in assessing the response to treatment.Methods Flow cytometric analysis was performed to look at the numbers of NK ceils in peripheral blood,synovial fluid,synovial membrane,expression of signalling molecule and cytokine-producing capacity of NK cells.The correlation between the change of NK cells and egicacy to monoclonal antibody against tumor necrosis factor(TNF) in the treatment of active RA was also studied.Results Compared to healthy controls,the number of peripheral blood CD3-CD56~+ NK cells was significantly decreased(8.95±3.72 vs.5.31±5.07,P0.05).The numbers of CD3-CD56~+ and CD3-CD247~+ NK cells were dramatically decreased in synovial fluid and synovial membrane compared to the paired peripheral blood in RA patients(P0.05).The expression of signalling molecule CD247 was also down-regulated in RA synovium.1.4%and 15.33%of the peripheral blood mononuclear cells produced interferonγwhen stimulated respectively by interleukin-12 combined with interleukin-18 and phorbol myristate acetate combined with ionomycin,however the significant increase of interferonγproduced by NK cells was not shown.After commencing TNF monoclonal antibody treatment for 14 weeks,increased NK cells was observed in 4 out of 5 good responders or moderate responders.Conclusions The numbers of NK cells in both circulation and inflammation sites were decreased,meanwhile the capacity of signalling transduction and cytokine-production were also impaired in RA.These phenomena were correlated to the chronic inflammation in RA.With clinical improvement after TNF monoclonal antibody therapy,the tendency of increased peripheral NK cells was observed.Monitoring NK ceils could be helpful for efficacy assessment." @default.
- W2382384811 created "2016-06-24" @default.
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- W2382384811 date "2008-01-01" @default.
- W2382384811 modified "2023-09-25" @default.
- W2382384811 title "Characterizations of Natural Killer Cells in Peripheral Blood,Synovial Fluid and Membranl of Patients with Rheumatoid Arthritis" @default.
- W2382384811 hasPublicationYear "2008" @default.
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