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- W2382393050 abstract "To separate main analgesic fraction from venom of Guangdong Naja naja atra, to establish the basis for the using of Naja naja atra and find new analgesic fraction.Affinity chromatography and size exclusion were used to isolate the analgesic fraction from the venom of Naja naja atra, and then to determine its properties by biochemical methods, such as SDS-polyacryamide gel electrophoresis ( SDS-PAGE), HPLC and Mole-toff.HPLC showed its relative purity was 95% (HPLC)and Mw was 6741. 236 Da. We observed that peripheral administration of neurotoxin strongly reduced the mechanical allogynia and thermal hyperalgesia for 24 hours, associated with this neuropathy (L5 spinal nerve ligation).The fraction from venom of Naja naja atra has significant analgesic effect and it is worth further developing." @default.
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- W2382393050 date "2009-07-01" @default.
- W2382393050 modified "2023-10-06" @default.
- W2382393050 title "[Isolation and pharmacological properties of analgesic fraction from venom of Naja Naja atra]." @default.
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