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- W2382412971 abstract "To look for the further evidence for HPV L1 -16 E6 and -18 E6 as carcinogenic factors in laryngeal carcinoma,we investigated their expressions in laryngeal carcinoma.We examined representative numbers of specimens from laryngeal cancer and controls with highly sensitive PCR technique for the presence of HPV L1 and high-risk types HPV16 E6 and HPV18 E6.PCR detection revealed that 76.42% samples were HPV L1 positive,54.47% were HPV16 E6 positive,58.54% were HPV-16E7 positive,42.28% were HPV-18E6 positive,and 48.78% were HPV-18E7 positive.PCR screen of HPV infection in control crowd showed that the prevalence of HPV-16E7 was similar to that of HPV-16E6.The prevalence of HPV-16E6 was lower than that of laryngeal carcinoma.But,as the cells undergoing pathological progress,the HPV-16E6 positive rate was increased.The positive rate of HPV-L1 was the higher as compared with HPV-16E6/E7.Furthermore,the prevalence of HP V-L1 was significantly increased as the cells undergoing pathological progress.These results suggested that HPV-16 plays a significant role in the pathogenesis of laryngeal carcinoma;integration of E6 and E7 into host genome and stable expression of these genes may be associated with the carcinogenesis of laryngeal epithelium cells.In addition,HPV-16 and HPV-18 may synergistically function on the pathogenesis of laryngeal epithelium.And L1 segment is fit for examining HPV infection." @default.
- W2382412971 created "2016-06-24" @default.
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- W2382412971 date "2010-01-01" @default.
- W2382412971 modified "2023-09-26" @default.
- W2382412971 title "Expressions of HPV-L1 and -16/18 DNA in laryngeal carcinoma" @default.
- W2382412971 hasPublicationYear "2010" @default.
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