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- W2382415107 abstract "AIM:To identify CFTR Cl-channel gating potentiators from natural compounds.METHODS:A stably transfected Fischer thyroid epithelial(FRT)cell line co-expressing human CFTR and a green fluorescent protein mutant with ultra-high halide sensitivity(YFP-H148Q)was used to measure CFTR-mediated iodide influx rate stimulated by the 386 natural compounds.RESULTS:Nuciferine was identified as an effective activator of wild-type CFTR chloride channel by screening of 386 single compounds from Chinese medicinal herbs.The CFTR-stimulating activity is rapid and reversible.Nuciferine does not elevate cellular cAMP level and activates phophorylated CFTR,suggesting that it works by direct binding to CFTR molecule.Nuciferine can also potentiate the Cl-transport of △F508 mutant CFTR.CONCLUSION:Nuciferine was identified as an effective CFTR chloride channel activator.Nuciferine may be useful for probing CFTR channel gating mechanisms and as a lead compound to develop pharmacological therapy of CFTR-related disease such as cystic fibrosis,idiopathic chronic pancreatiti,keratoconjunctivitis sicca and habitual constipation." @default.
- W2382415107 created "2016-06-24" @default.
- W2382415107 creator A5001179479 @default.
- W2382415107 date "2008-01-01" @default.
- W2382415107 modified "2023-09-28" @default.
- W2382415107 title "Natural compound nuciferine activates chloride channel of wild type and △F508 mutant cystic fibrosis transmembrane conductance regulator" @default.
- W2382415107 hasPublicationYear "2008" @default.
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