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- W2382426211 abstract "Objective: To study effects of glutamate receptor blockade on behavior and Fos expression in the basal ganglia of Parkinsonian rats with abnormal involuntary movements( AIM) ,and to explore effects of glutamate on changes in activity of striaturn efferent pathway after repetitive levodopatreatment. Methods; Unilateral 6-hvdroxydopamine-lesioned rat model of Parkinson's disease(PD)wastreated with levodopa/benserazide twice daily for 4 weeks. On day 29,the animals were given an acute systemic administration ofMK-801 15min prior to levodopa treatment to observe the behavior changes and 2 hour late,rats were sacrificed and immunohistochemical technique was used to measure changes of Fosexpression in the caudate-putanlen and globus pallidus. Results: Pulsatile treatment with a subthresholddose of levodopa gradually induced AIM,including stereotypydimb dyskinesia,axial dystoma andmastlcatory dyskinesia)towards the side contralateral tO the dopamine-denervated stnatum,and increased contraverslve rotatmn Pretreatment with the non-competmve NMDA antagonist,MK-801, preventedstereotypy but increased contraverslve rotaUon Fos expression ofthe lesioned hemisphere was increased in the caudate-putamen and reduced in the globus pallidus of rats with AIM by MK-801. Conclusions; The neural mechanism underlying levodopa-induced AIM and shorter duration of rotatmn in rat model of PD was very similar to those seen in levodopa-induced dyskinesia(LID)and wearing-off in PD patients and MPTP. treated monkeys, and glutamate may play an important role in pathogenesis Of LID. Glutamate receptor blockade may prevent occurrence of LID and wearing-off through reversing activity of directoutput pathway." @default.
- W2382426211 created "2016-06-24" @default.
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- W2382426211 date "2004-01-01" @default.
- W2382426211 modified "2023-10-15" @default.
- W2382426211 title "Effect of MK801 on neuronal activity in the basal ganglia in a rat model of PD with levodopa-induced abnormal involuntary movement" @default.
- W2382426211 hasPublicationYear "2004" @default.
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