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- W2382450695 abstract "Objective To observe the interventional effects of two administration ways of Kuijie Decoction,gavage and enteroclysis,on the levels of serum interferon-γ(IFN-γ) and interleukin-4(IL-4) and ratio of IFN-γto IL-4.Methods All rats were randomly divided into the normal group(given distilled water) ,model group(given distilled water) ,olsalazine sodium control group(given olsalazine sodium) ,gavage group(intragastrical administration of Kuijie Decoction) and enteroclysis group(colonic administration of Kuijie Decoction) .The model was established by TNBS/ethanol method in all groups except the normal group(normal feeding) .After 7,14 and 28 days,the blood samples were collected respectively and the levels of serum IL-4 and IFN-γwere detected in rats of all groups by using ELISA.Results Kuijie Decoction administrated by two ways decreased significantly the level of serum IL-4 and increased the level of IFN-γ,regulated the ratio of IFN-γto IL-4,and inhibited ulcerative colitis(UC) tending to the inflammation mediated by Th1 cells.The effect of gavage was better than that of enteroclysis in acute stage of UC(P0.05) and vice versa in middle and late stage. The comparison showed a statistical significance(P0.05) .Conclusion Kuijie Decoction administrated by two ways has the same mechanism in the immunoregulation on UC.The effect of gavage was better than that of enteroclysis in acute stage and vice versa in middle and late stage.It will get better curativeeffect to change the administration way according to the stages of the disease." @default.
- W2382450695 created "2016-06-24" @default.
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- W2382450695 date "2010-01-01" @default.
- W2382450695 modified "2023-09-25" @default.
- W2382450695 title "Influences of Kuijie Decoction administrated by two ways on levels of serum IFN-γ and IL-4 in rats with ulcerative colitis" @default.
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