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- W2382452425 abstract "Objective To study effects of ultrasound-mediated microbubble destruction in myocardium-targeted delivery of autologus bone marrow mesenchymal stem cells(BMMSCs) to treat acute myocardial infarction by improving heart function.Methods BMMSCs of 14 Chinese minipigs,aged 3-4 months old,were selected,cultured and labeled by suerparamagnetic iron oxide.AMI model was made by blocking blood stream of left anterior descending branch.Pigs were devided into 2 groups:experiment group(BMMSCs+Utrasound+Bubble,n=8) and control group(BMMSCs,n=6).After 7 days,BMMSCs were transplanted into AMI areas of each host heart through intracoronary way.64-slice multidetector computed tomography were performed to observe left ventricular function 1 day before and 6 weeks after transplantion.The histological analysis was conducted.Results Compared to the control group,the heart function was improved more significantinly in the experiment group.The capillary numbers of experiment group were more than those of the control group(16.37±3.20 vs 9.50±1.87,P0.05),the prussian blue-positive stained cells in experiment group outnumbered those in the control group(71.63±14.09 vs 40.67± 9.48,P0.05),so did the desmin-positive cells(31.88±4.16 vs 19.00±2.28,P0.05).ConclusionUltrasound-mediated microbubble destruction shows favorable effects on myocardium delivery of autologus BMMSCs to treat acute myocardial infarction by improving heart function and angiogenesis." @default.
- W2382452425 created "2016-06-24" @default.
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- W2382452425 date "2008-01-01" @default.
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- W2382452425 title "Experimental study of ultrasound-mediated microbubble destruction in myocardium-targeted delivery of bone marrow mesenchymal stem cells to treat myocardial infarction" @default.
- W2382452425 hasPublicationYear "2008" @default.
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