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- W2382462022 abstract "Objectives To investigate the role of macrophage migration inhibitory factor(MIF) in the regulation of Ttype calcium channels(ICa,T) in atrial myocytes.Methods The whole-cell voltage-clamp technique and biochemical assays were used to detect the regulation of ICa,T in atrial myocytes.Results In atrium-derived myocytes(HL-1cells) cultured in vitro, mouse recombinant MIF(20 or 40 nmol / L,24 h) could significantly suppress peak ICa,T when compared with control group [(-17.5±2.9) pA / pF vs.(-27.9±3.4) pA / pF, P0.05;(-11.3±1.7) pA / pF vs.(-27.9 ±3.4)pA / pF,P 0.01],impair the voltage-dependent activation of ICa,T and down-regulate the expressions ofα1G and α1H mRNA of T-type calcium channels.The reduction of ICa,T induced by 40 nmol / L recombinant MIF could be reversed by genistein and PP1 [genistein:(-11.3±1.7) pA / pF vs.(-16.1±0.8),P0.05; PPI:(-11.3±1.7) pA / pF vs.(-19.0 ±3.2) pA / pF,P 0.05 ].Conclusions MIF may be involved in the pathogenesis of atrial fibrillation by affecting the ICa,T in atrium-derived myocytes,in which Src may take part in the signal transduction pathway." @default.
- W2382462022 created "2016-06-24" @default.
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- W2382462022 date "2013-01-01" @default.
- W2382462022 modified "2023-09-26" @default.
- W2382462022 title "Regulation of macrophage migration inhibitory factor on T-type calcium channels in HL-1 cells" @default.
- W2382462022 hasPublicationYear "2013" @default.
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