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- W2382464958 abstract "Objective To establish a practical and reproducible animal model of acute-on-chronic liver failure,which is similar to the histopathology in human beings,we attacked the immunological cirrhosis rats with three means.Methods Immunological hepatic cirrhosis was induced by human serum albumin in Wistar rats.Rats with early-stage cirrhosis(fibrosis stage IV) were randomly divided into 4 groups.D-galactosamine(1.2 g/kg) was intraperitoneally administered in group 1(n=6).Rats in group 2(n=6) were treated with lipopolysaccharide(30 mg/kg).D-galactosamine(400 mg/kg) and lipopolysaccharide(100 μg/kg) were simultaneously injected in group 3(n=10),while group 4(n=4) were intravenous injected with human albumin as before.Survival time was observed,and liver injury was assessed by histopathology,as well kidney and lung.Results Hepatic fibrosis was detected after albumin intravenous injection for 6 weeks.Five rats died in group 1 after treatment with D-galactosamine,with survival time of 39 to 52 hours.Histopathology revealed severely adipose degeneration in regenerative nodules,only pelleta necrosis were seen.In group 2,rats experienced lethargy,febrile shaking and diarrhea,with fully recovery after 24 hours,three rats were sacrificed on 3 days,with no signs of necrosis in liver section.In group 3,5 rats died from severe liver failure,with survival time of 13~19 hours.Histology of liver section revealed massive necrosis in nodules,with significant apoptosis of hepatocytes.Conclusion The experimental model of acute-on-chronic liver failure,induced by D-galactosamine/lipopolysaccharide in rats with immunological liver fibrosis,showed similar morphological changes as human beings,while D-galactosamine or lipopolysaccharide alone failed to sacrifice cirrhosis rats from liver massive necrosis." @default.
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- W2382464958 date "2008-01-01" @default.
- W2382464958 modified "2023-09-28" @default.
- W2382464958 title "Exploration of establishing rat model of ACLF in human serum albumin-induced cirrhosis" @default.
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