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- W2382474983 abstract "Objective To investigate the biologic effects of tumour necrosis factor α(TNF α) on scar|derived fibroblasts and to evaluate the role of TNF α in genesis ,prevention and treatment of scar. Methods Cell strains were established by tissue culture technique. To study the fibroblasts derived from hypertrophic scar and normal dermis,cytoactivity and expression of fibronectin (FN) were determined by MTT,FCM and immunofluorescence. Results① When TNF α is at a high concentration (1?000U/ml ↑),the cytoactivity of hypertrophic scar fibroblasts was decreased significantly,and the positive rate of FN expression was decreased by 11.7%. ② Cytoactivity of normal dermis fibroblasts was increased with TNF α while the positive rate of FN expression was increased by 9.6%. Conclusions TNF α has different biological effects on fibroblasts derived from hypertrophic scar or normal dermis. Studying the regulative mechanisms of TNF on abnormal scar will probably provide a new way to prevent and cure it." @default.
- W2382474983 created "2016-06-24" @default.
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- W2382474983 date "2000-01-01" @default.
- W2382474983 modified "2023-09-24" @default.
- W2382474983 title "Experimental study of biologicd effects of tumour necrosis factor-α on scar-derived fibroblasts" @default.
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