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- W2382476021 abstract "Objective To explore the impact of hydrogen sulfide(H2S) on post-burn inflammatory response in rats through analyzing the change of H2S in blood serum as well as the change of C-reaction protein(CRP),IL-6 and total antioxidant capacity(TAOC) under different H2S levelS.Methods Seventy-eight male SD rats were randomly setected,72 of whom were prepared as 30% TBSA full thickness burn model,and randomly divided into simple burn group,NaHS group and PPG group(24 rats in each group);the remained 6 rats were selected as burn group,to collect the blood serum of rats at 6 h,12 h,24 h and 48 h respectively.The sulfur sensitive electrode method was used for the determination of serum H2S concentrations,to analyze the change of CRP,IL-6 and TAOC with relevant testing kits.Results Compared with the none burn group,the H2S level in te simple burn group decreased at each time point,especially at 6 h(35.18±5.46)μmol/L and 12 h(52.20±5.06)μmol/L,P0.05;CRP,IL-6 significantly increased and TOAC decreased(P0.05) at each time point;compared with simple burn group,H2S level in NaHS group significantly increased at 6 h(54.77±3.12)μmol/L),12 h(52.20±5.06)μmol/L and 24 h(50.91±3.80)μmol/L post burn,P0.05;compared with simple burn group,in the PPG group,CRP and IL-6 increased,H2s level and TOAC decreased at different time point(P0.05).Conclusion Through studying the impact of H2S on IL-6,CRP,and TOAC in blood serum of burned rats the results,further indicated the anti-inflammatory and antioxidant effects of H2S,but whether H2S could be a new therapeutic direction in severe burn inflammation still needs more research." @default.
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- W2382476021 date "2012-01-01" @default.
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- W2382476021 title "The impact of hydrogen sulfide on post-burn inflammatory response in rats" @default.
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