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- W2382482893 abstract "Objective To study regional cerebral glucose utilization with 18F-fluorodeoxyglucose (FDG)/PET in advanced Parkinson's disease (PD), and investigate the imaging characteristics of advanced PD patients.Methods Eight advanced Parkinson's diseases patients (5 men, 3 women; mean age 63.5±3.7;mean H-Y disability scale 4.1±0.5) and 8 age-matched healthy subjects underwent 18F-FDG/PET examinations at resting-state . Statistical parametric mapping (SPM) was usedto investigate regional cerebral metabolic rate of glucose (rCMRGlu). Results Compared to age-matched healthy subjects, the regional glucose metabolism increased in both thalamus, precentral cortex(BA6) and lentiform and decreased in both prefrontal motor area (BA46), parietal-occipital area as defined in the atlas of Talairach and Tournoux (P0.001)in advanced PD cases.Conclusions Hypermetabolism in thalamus and lentiform accompany with hypometabolism in prefrontal motor area and parietal-occipital cortex can be found in advanced PD patients, and this special regional cerebral metabolism pattern is helpful to diagnosis and investigates the pathophysiology of PD." @default.
- W2382482893 created "2016-06-24" @default.
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- W2382482893 date "2003-01-01" @default.
- W2382482893 modified "2023-09-23" @default.
- W2382482893 title "A~(18)F-fluorodeoxyglucose (FDG)/PET study of advanced Parkinson's disease" @default.
- W2382482893 hasPublicationYear "2003" @default.
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