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- W2382507743 abstract "Objective: To investigate if dehydroxy methyl epoxy quinomicin (DHMEQ), a novel nuclear factor-kappaB (NF-κB) inhibitor, can enhance docetaxel’s anti-tumor activity in anaplastic thyroid cancer (ATC) cell (FRO) xenograft in nude mice. Methods: FRO xenograft nu/nu mouse models were created by injecting 5×106 cells on both flanks. The dosages of drugs were determined as intraperitoneal (i.p.) injection with 5 mg/kg of docetaxel once a week, daily i.p. injection with 6 mg/kg of DHMEQ for two weeks; combined treatment was given with both drugs; and mice of control group received vehicle injections only. Tumor dimensions were monitored for 32 days. One day after treatment, TUNEL apoptotic staining was performed in excised tumor tissues. Results: Although no drugs showed the effect of the treatment on the reduced tumor growth, the combined treatment of DHMEQ and docetaxel was much more effective for two weeks (F treatment = 54.05,F time = 300.18,F interaction = 70.06,P 0.01). The TUNEL apoptotic staining showed that combined treatment induced much more apoptotic cells in com-parison with that of single drug treatment. Apoptotic indices demonstrated the significant differences between the groups. Specifically, single drug treatment induced many positive cells, while the combined regiment tremendously increased positive cells(P 0.01). Conclusion: Docetaxel is able to induce NF-κB signaling pathway in cancer cells, which could attenuate antitumor activities of the drugs. NF-κB inhibitor can effectively suppress this phenomenon and create chemo-sensitive environment, and synergistically enhance the apoptosis." @default.
- W2382507743 created "2016-06-24" @default.
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- W2382507743 date "2010-01-01" @default.
- W2382507743 modified "2023-09-23" @default.
- W2382507743 title "Combination of NF-κB Inhibitor and Docetaxel Enhances Anti-tumor Activity in Anaplastic Thyroid Cancer Cell Xenograft in Vivo" @default.
- W2382507743 hasPublicationYear "2010" @default.
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