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- W2382521189 abstract "Objective To investigate the expression of matrix metalloproteinase 2(MMP-2),tissue inhibitor of metalloproteinase 1(TIMP-1) and tissue inhibitor of metalloproteinase 2(TIMP-2) in chorionic villi and deciduas from spontaneous abortion women.Methods Immunohistochemical method(S-P) was employed to detect the expression of MMP-2 and TIMP-2 in chorionic villi and deciduas from women with spontaneous abortion(31 cases) and normal pregnant women(36 cases).Reverse transcriptase-ploymerase chain reaction(RT-PCR) was used to detect mRNA expression levels of MMP-2 and TIMP-1 in chorionic villi.Results There was no significant difference of MMP-2 expression in the two groups.While the strong positive(degree Ⅲ) expression rate of TIMP-2 in chorionic villi and deciduas from abortion group was significantly lower than that in the normal pregnant group(P0.01),and the mRNA expression level of TIMP-1 was significantly lower than that in the control group too(P0.05).Conclusions The higher ratio of MMP-2 to TIMP-1 or TIMP-2 in chorionic villi and deciduas,as a result of the normal expression of MMP-2 and the decreased expression of TIMP-1 and TIMP-2,may contribute to the spontaneous abortion." @default.
- W2382521189 created "2016-06-24" @default.
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- W2382521189 date "2010-01-01" @default.
- W2382521189 modified "2023-09-24" @default.
- W2382521189 title "Expression of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-1,2 in chorionic villi and deciduas from women with spontaneous abortion" @default.
- W2382521189 hasPublicationYear "2010" @default.
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