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- W2382540632 abstract "Objective: To investigate the therapeutical effects of Polyene Phosphatidyl Choline(PPC) on β-amyloid(1-40) induced Alzheimer 's Disease model Rat.Methods: Thirty-two Sprague-Dawley rats were divided into four groups: normal control group,sham control group,model group and PPC treatment group.β-Amyloid protein was infused into the hippocampal fissure of rats to produce Alzheimer's Disease(AD) model and the treatment group rats were given PPC.Morris water maze was detected to evaluate the cognition behavior of learning and memory.The histological and immunohistochemistry staining were used to observe the hippocampus changes caused by PPC treatment in the AD model rats.Results:①Compared that in the normal control group and sham control group,learning and memory latency of the model group was prolonged significantly(P0.05);As it to PPC treatment group,compared with Model group,learning and memory latency was significantly shortened(P0.05);The differences between groups were statistically significant(P0.05).② Nissl staining: compared the model group with the normal control group,sham control group,the results were significantly differences(P0.05);compared the PPC treatment group with the model group,the result was significantly different(P 0.05);comparing the treatment group with the normal control group and the sham control group,the results also show significant difference(P 0.05).③Aβimmunohistochemical staining: Compared with normal control group and sham control group,the model group show obvious increasing amount of β-amyloid deposits;Compared with model group,the PPC treatment group indicate significant decreasing of the number of β-amyloid deposits.Conclusion: Polyene phosphatidyl Choline had therapeutical effects on Alzheimer's Disease model rats induced by β-amyloid protein(1-40)." @default.
- W2382540632 created "2016-06-24" @default.
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- W2382540632 date "2011-01-01" @default.
- W2382540632 modified "2023-09-22" @default.
- W2382540632 title "Polyene Phosphatidyl Choline for Alzheimer's Disease Model Rats Induced by β-Amyloid Protein(1-40)" @default.
- W2382540632 hasPublicationYear "2011" @default.
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