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- W2382556868 abstract "Objective To explore if exogenous retinoic acid(RA) can reverse the toxicity of ethanol on zebrafish embryonic development.Methods The expression of nkx2.5 in zebrafish embryos which treated with RA,ethanol and diethylaminoben zaldehyde(DEAB) was detected by in situ hybridization,the expressions of gata5,gata6 and raldh2 in zebrafish embryos which treated with RA,ethanol and DEAB were detected by reverse transcriptase-polymerase chain reaction(RT-PCR).Also,the expressions of gata5,gata6 in zebrafish embryos which knock-out raldh2 gene were detected by RT-PCR.Results When treated with RA and alcohol,embryos developed more abnormal,cardiac primordia could not be confused into single primitive heart tube.When treated with alcohol,the expression of nkx2.5 was up-regulated and heart-looping could not be finished.The expressions of gata5,gata6 and raldh2 were slightly up-regulated when treated with RA and alcohol,but when knocking-out raldh2,the expressions of gata5,gata6 were down-regulated.When treated with DEAB,the heart tube fusion could be finished.Alcohol treated at 300 mmol·L-1 could affect the heart tube fusion which was similar to the appearance of 200 mmol·L-1 RA and ethanol treated together.Conclusions Ethanol can affect heart looping through up-regulating the expression of nkx2.5 gene.Ethanol together with RA can aggravate the malformation of heart development through affecting the fusion of heart tube,and this might be due to the reduced metabolism of ethanol but not the expression changes of gata5 and gata6 gene.RA signaling can regulate the expressions of gata5 and gata6." @default.
- W2382556868 created "2016-06-24" @default.
- W2382556868 creator A5060661638 @default.
- W2382556868 date "2010-01-01" @default.
- W2382556868 modified "2023-09-23" @default.
- W2382556868 title "Effect of Ethanol on Malformation of Heart Develoment of Zebrafish Induced by Retinoic Acid" @default.
- W2382556868 hasPublicationYear "2010" @default.
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