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- W2382564189 abstract "Objective:To investigate the function of Survivin in the development of ovary epidermis cancer,and to evaluate the effect of JAK inhibitor AG490 on the expression of Survivin g in ovary epidermis cancer cell line SKOV3.Methods:Cell cycle and apoptosis of SKOV3 cells were analyzed by flow cytometry.The expression of STAT3,p-STAT3,and the Survivin were assayed by immunohistochemistry.Results:Flow cytometry results showed that SKOV3 mitotic cycle was arrested in the G2/M stage,and the apoptosis rate increased after AG490 treatment(P0.05).The expression rates of p-STAT3 and Survivin were decreased from 58.95% and 56.91% respectively to 20.67% and 16.24% respectively after AG490 treatment.Conclusion:In SKOV3 cells,AG490,the inhibitor of JAK,blocks the activation of STAT,inhibits the p-STAT3 expression and thus inhibits the expression of Survivin,promotes the apoptosis rate,and suppresses the proliferation of tumor cells.It is suggested that Survivin would be an important suppressor gene for the development of ovary epidermis cancer." @default.
- W2382564189 created "2016-06-24" @default.
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- W2382564189 date "2011-01-01" @default.
- W2382564189 modified "2023-10-07" @default.
- W2382564189 title "Effects of JAK Inhibitor AG490 on the Expression of Survivin Gene in the Ovary Epidermis Cancer Development" @default.
- W2382564189 hasPublicationYear "2011" @default.
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