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- W2382565202 abstract "Objective To develop a model of liver hy pothermic irrigation and reperfusion in situ in Sprague Dawley rat for experimen tal research in ex situ liver surgery and in procurement of living-related live r graft. Methods Seventy-eight male Sprague Dawley rats (250～3 00 g) were randomly divided into four groups: ischemic-reperfusion (I-R) group (group D, n=24), lactate Ringer's group (group A,n=24),self-design ed solution group(group B,n=24) and non-ischemic control (group C,n=6). Th e splenic vein and the right adrenal vein were utilized as the afferent and the efferent channel in hypothermic irrigation in situ. The morphological changes th at occurred in livers after 2 and 6h reperfusion were observed under light a nd electron microscopy. The damage to the sinusoidal endothelium was estimated b y measuring circulating hyaluronic acid (HA).Results The HA levels in the plasma after 2 and 6h repe rfusion in the group C were(250.0±24.1)μg/L,(290.4±37.0)μg/L respect ively. The HA values in the group A [(142.9±30.1)μg/L,P0.01],[(20 0.0±17.5)μg/L,P0.01]and in group B [(63.3±16.2)μg/L,P0.01 ],[(62.1±14.6)μg/L,P0.01]were decreased as compared with group C, respectively. In the group B HA level was statistically lower than in the group A (P0.01). The operative procedure was simple without any stitch on th e ma in vein around the liver. Total blood loss was less than 0.5 ml. The damage to h epatic and sinusoidal endothelial cells was reduced by the hypothermic irrigatio n with self-designed solution.Conclusion This model can accurately reflect pathophysio logical changes of procudure in ex situ liver surgery and in procurement of livi ng-related liver graft." @default.
- W2382565202 created "2016-06-24" @default.
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- W2382565202 date "2001-01-01" @default.
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- W2382565202 title "Development and implication of a rat model of liver hypo thermic irrigation and reperfusion in situ" @default.
- W2382565202 hasPublicationYear "2001" @default.
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