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- W2382604842 abstract "AIM To study the mRNA expression of histamine H_1 receptor in hepatocarcinoma of rats. METHODS Dimethylamino-azobenzene (DAB) was used to induce hepatocarcinoma in rats. Semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) was adopted to analyse the relative expression of histamine H_1 receptor. And the base sequence of its PCR product was detected. RESULTS The relative mRNA expression of histamine H_1 receptor was significantly decreased in hepatic carcinoma tissue, compared with that part far from cancer and control group (P0.01, respectively). And gene mutation was detected in the base sequence of H_1 receptor mRNA in hepatic carcinoma tissue. CONCLUSION Decrease in mRNA expression of histamine H_1, receptor and point mutation to H_1 receptor gene may play a role in the occurrence and development of rats' hepatocarcinoma induced by DAB.-" @default.
- W2382604842 created "2016-06-24" @default.
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- W2382604842 date "2004-01-01" @default.
- W2382604842 modified "2023-09-25" @default.
- W2382604842 title "Expression of histamine H_1 receptor gene in hepatocarcinoma of rats induced by dimethylamino-azobenzene" @default.
- W2382604842 hasPublicationYear "2004" @default.
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