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- W2382609715 abstract "Purpose To examine the effect of iNOS on tumour cells chemosensitivity to a series of antineoplastic drugs in vitro and to clarify the possible role of iNOS in the metabolism of 2,5-biaziridinyl-6-hydroxy-methyl-3-methylbenzene-1,4-dione (RH1), a new synthesized bioreductive compound. Methods Human breast cancer cell line (MDA-MB-231~ wt ) and its iNOS gene transfected clones (iNOS10) were exposed to aforementioned anticancer drugs and RH1. 3-4,5 dimethylthiazol-2-yl-2,5-diphenyl-tetrazolium bromide (MTT) assay were used to determine cells sensitivity, the change of cell cycle different timepoint after exposed in 0.01μmol/L RH1 were plot by flow cytometric analysis. Results iNOS-gene transferred cells(iNOS10) showed resistance to CDDP, MMC, mephalan and mitoxantrone compared to parent cells MDA-MB-231~ wt and control cells PEF. However, iNOS10 cells were more sensitive to ADM. On the other hand, the toxicity of RH1 was more severe than MMC. RH1 enhanced cytotoxicity under hypoxia and could cause cell block in G_2/M phase 24 hours after it was administrated. Conclusions Cells with high iNOS activity showed resistance to part of the antineoplastic drugs, it might because that iNOS could catalyse drugs into their non- or low-toxic production. And in the metabolism activation of RH1, iNOS could enhance or decrease the cytotoxicity of RH1 depending on the intracellur PO_2, which caused higher cytotoxicity of RH1 to hypoxia cells with the increasing of iNOS activity." @default.
- W2382609715 created "2016-06-24" @default.
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- W2382609715 date "2006-01-01" @default.
- W2382609715 modified "2023-09-26" @default.
- W2382609715 title "Effect of inducible nitric oxide synthase (iNOS) on chemosensitivity of a breast cancer cell MDA-MB-231~(wt)" @default.
- W2382609715 hasPublicationYear "2006" @default.
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