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- W2382632594 abstract "OBJECTIVE To investigate the protective effects of oxysophoridine(OSR) on cerebral ischemia and reperfusion injury(CIRI) in mice and to explore its possible protective mechanism.METHODS The CIRI model of mice was induced with an 6/0nylon monofilament coated with silicone hardener mixture via the internal carotid artery.Brain water content was determined by dry/wet weight method and the cerebral index was counted in mice.The expression of NMDA NR1mRNA and the expression of NMDA NR1protein were tested with the method of Real-time RT-PCR and Western blot in mice.RESULTS Compared with the model group,OSR(62.5,125,250 mg·kg-1) and nimodipine(6 mg·kg-1) reduced the brain water content(P 0.01).OSR(125,250 mg·kg-1) and nimodipine(6 mg·kg-1) reduced the cerebral index(P 0.05,P 0.01).mRNA and protein expression of NMDA NR1were decreased by OSR(250 mg·kg-1) and nimodipine(6 mg·kg-1)(P 0.01).CONCLUSION OSR has significantly protective effects of CIRI in mice,the effective mechanism of OSR might relate to inhibit the expression of NMDA NR1receptor." @default.
- W2382632594 created "2016-06-24" @default.
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- W2382632594 date "2013-01-01" @default.
- W2382632594 modified "2023-09-24" @default.
- W2382632594 title "Effects of oxysophoridine on NMDA NR_1 expression in the brain tissue of mice with cerebral ischemia and reperfusion injury" @default.
- W2382632594 hasPublicationYear "2013" @default.
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