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- W2382635242 abstract "【Objective】 Adiponectin have gained attention in the pathogenesis of fibrogenesis in various chronic liver diseases.However,the roles of adiponectin in the progression of hepatic fibrosis and inflammation in patients with chronic hepatitis B virus(HBV) infection are poorly understood.The purposes of this study are to evaluate possible associations of serum levels of adiponectin with progression of hepatic fibrosis and inflammation in patients with chronic HBV infection.【Methods】 Serum adiponectin concentration was measured by an enzyme-linked immunosorbent assay.Subjects included in this study are 35 patients with chronic hepatitis B(CHB) and 24 normal controls(NC).Histologic activity index(HAI) of inflammation and Knodell fibrosis were scored in 35 patients with CHB,patients with and under G2 stage were included as mild inflammation and patients above G2 stage were included as advanced inflammation,patients with and under S2 stage were included as mild fibrosis and patients above S2 stage were included as advanced fibrosis.【Results】 Serum levels of adiponectin in patients with mild fibrosis,advanced fibrosis were significantly lower than those in NC.Serum levels of adiponectin in patients with mild inflammation,advanced inflammation were significantly lower than those in NC.We found that in patients with the same histologic activity index,there was no significant difference between patients with mild and advanced fibrosis.【Conclusion】 Serum levels of adiponectin decrease as hepatic inflammation and fibrosis progression in patients with chronic HBV infection,and our results indicate that serum levels of adiponectin correlate more closely with the degrees of hepatic inflammation other than the stages of hepatic fibrosis in patients with chronic HBV infection." @default.
- W2382635242 created "2016-06-24" @default.
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- W2382635242 date "2011-01-01" @default.
- W2382635242 modified "2023-09-23" @default.
- W2382635242 title "Serum levels of adiponectin in patients with chronic hepatitis B virus infection are decreased and associated with hepatic fibrosis and inflammation progression" @default.
- W2382635242 hasPublicationYear "2011" @default.
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