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- W2382674283 abstract "Objective To assess the efficacy and safety of imatinib mesylate in the treatment of patients with chronic myelogenous leukemia(CML).Methods Fifty-one CML patients were treated with imatinib.The responses in hematology,cytogenetics,molecule and adverse reactions,total survival and progression of the disease were observed.Results After three months of therapy,97.8%(45/46) of the patients in chronic phase achieved complete hematologic response(CHR);After one year of medication,79.4%(27/34) reached complete cytogenetic response,5.9%(2/34) achieved partial cytogenetic response,2.9%(1/34) obtained minor cytogenetic response,5.9%(2/34) got minimal cytogenetic response,5.9%(2/34) did not get cytogenetic response,and patients with complete molecular response accounted for 29.4%(10/34).The total one-,two-and three-year survi-val rates were 100.0%,97.0%,and 91.6%,respectively;and that of survival with no disease-progression was100.0%,85.3% and 73.1%.In three patients with accelerated phase,one reached CHR,one obtained complete cytogenetic response and one got partial cytogenetic response.Two patients in blastic phase died,their course of disease being nine and 15 months,respectively.Conclusion Therapy with imatinib for CML patients in chronic phase can obtain a high hematologic and cytogenetic response with little side effects,whereas the outcomes for those in accelerated and blastic are below the mark." @default.
- W2382674283 created "2016-06-24" @default.
- W2382674283 creator A5061908529 @default.
- W2382674283 date "2012-01-01" @default.
- W2382674283 modified "2023-09-28" @default.
- W2382674283 title "IMATINIB MESYLATE IN THE TREATMENT OF CHRONIC MYELOGENOUS LEUKEMIA: AN EFFICACY AND SAFETY EVALULATION" @default.
- W2382674283 hasPublicationYear "2012" @default.
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