Matches in SemOpenAlex for { <https://semopenalex.org/work/W2382695504> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2382695504 abstract "By the determination of colony formation rate of tumor cells in culture,the increase percentage in life -span (%) of tumor-bearing mice, and solid tumor growth in-hibitizon rate in mice, the dose-response relationship of cisplatin (DDP) and adriamycin (AD-M) combination therapy was evaluated in experiments in vivo and in vitro. DDP and ADM combination therapy showed additive effect on the antitumor activity. The obvious additive effect occured in bwer dose of these two drugs in combination. If the dose of one drug 1/4 of the effective dose combined with ineffective dose (1/16, 1/64 of effective dose) of another drug, the colony formation rate was decreassd obviously, but when the effective dose (DDP and 80 n mol/ml for DDP or ADM) of one drug was combined with a sub-effective dose of another drug,the colony formation rate did not deoease.The dose relationship in vivo was similar to that in vitro. The combination of ineffective doses (0.08, 0.25 or 0.05 mg/kg X 4 ) of two drugs may increase the value of ILS of mice bearing EAC to 215.6% (P0.01), it was dose-dependent When one drug was used in effective dose combined with the ineffective dose of another drug, the value of ILS did not increase obviously (P0.05), but the toxicity was increased. These results suggested that in dinical combination drug therapy the dose of single drug must be reduced,otherwise would be harmful" @default.
- W2382695504 created "2016-06-24" @default.
- W2382695504 creator A5079506254 @default.
- W2382695504 date "1992-01-01" @default.
- W2382695504 modified "2023-09-27" @default.
- W2382695504 title "THE RELATION BETWEEN DOSE ADD ANTITUMOR ACTIVITY OF CISPLATIN AND ADRIAMYCIN COMBINATION" @default.
- W2382695504 hasPublicationYear "1992" @default.
- W2382695504 type Work @default.
- W2382695504 sameAs 2382695504 @default.
- W2382695504 citedByCount "0" @default.
- W2382695504 crossrefType "journal-article" @default.
- W2382695504 hasAuthorship W2382695504A5079506254 @default.
- W2382695504 hasConcept C126322002 @default.
- W2382695504 hasConcept C149857219 @default.
- W2382695504 hasConcept C150903083 @default.
- W2382695504 hasConcept C185592680 @default.
- W2382695504 hasConcept C19831878 @default.
- W2382695504 hasConcept C202751555 @default.
- W2382695504 hasConcept C207001950 @default.
- W2382695504 hasConcept C2776694085 @default.
- W2382695504 hasConcept C2776999253 @default.
- W2382695504 hasConcept C2778239845 @default.
- W2382695504 hasConcept C2780035454 @default.
- W2382695504 hasConcept C29730261 @default.
- W2382695504 hasConcept C2989005 @default.
- W2382695504 hasConcept C55493867 @default.
- W2382695504 hasConcept C71924100 @default.
- W2382695504 hasConcept C86803240 @default.
- W2382695504 hasConcept C98274493 @default.
- W2382695504 hasConceptScore W2382695504C126322002 @default.
- W2382695504 hasConceptScore W2382695504C149857219 @default.
- W2382695504 hasConceptScore W2382695504C150903083 @default.
- W2382695504 hasConceptScore W2382695504C185592680 @default.
- W2382695504 hasConceptScore W2382695504C19831878 @default.
- W2382695504 hasConceptScore W2382695504C202751555 @default.
- W2382695504 hasConceptScore W2382695504C207001950 @default.
- W2382695504 hasConceptScore W2382695504C2776694085 @default.
- W2382695504 hasConceptScore W2382695504C2776999253 @default.
- W2382695504 hasConceptScore W2382695504C2778239845 @default.
- W2382695504 hasConceptScore W2382695504C2780035454 @default.
- W2382695504 hasConceptScore W2382695504C29730261 @default.
- W2382695504 hasConceptScore W2382695504C2989005 @default.
- W2382695504 hasConceptScore W2382695504C55493867 @default.
- W2382695504 hasConceptScore W2382695504C71924100 @default.
- W2382695504 hasConceptScore W2382695504C86803240 @default.
- W2382695504 hasConceptScore W2382695504C98274493 @default.
- W2382695504 hasLocation W23826955041 @default.
- W2382695504 hasOpenAccess W2382695504 @default.
- W2382695504 hasPrimaryLocation W23826955041 @default.
- W2382695504 hasRelatedWork W1549176003 @default.
- W2382695504 hasRelatedWork W1660925761 @default.
- W2382695504 hasRelatedWork W1972702230 @default.
- W2382695504 hasRelatedWork W2020389944 @default.
- W2382695504 hasRelatedWork W2030353822 @default.
- W2382695504 hasRelatedWork W2044449382 @default.
- W2382695504 hasRelatedWork W2062965163 @default.
- W2382695504 hasRelatedWork W2096122852 @default.
- W2382695504 hasRelatedWork W2134705779 @default.
- W2382695504 hasRelatedWork W2334903705 @default.
- W2382695504 hasRelatedWork W2357973822 @default.
- W2382695504 hasRelatedWork W2361046964 @default.
- W2382695504 hasRelatedWork W2371644941 @default.
- W2382695504 hasRelatedWork W2403344621 @default.
- W2382695504 hasRelatedWork W2409381853 @default.
- W2382695504 hasRelatedWork W2411546769 @default.
- W2382695504 hasRelatedWork W2414161678 @default.
- W2382695504 hasRelatedWork W2416959267 @default.
- W2382695504 hasRelatedWork W2417079461 @default.
- W2382695504 hasRelatedWork W2894441332 @default.
- W2382695504 isParatext "false" @default.
- W2382695504 isRetracted "false" @default.
- W2382695504 magId "2382695504" @default.
- W2382695504 workType "article" @default.