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- W2382701587 abstract "Objective To investigate the relationship between eosinophilic airway inflammation and exercise-induced bronchoconstriction(EIB),and the response to inhaled corticosteroids(ICS) therapy.Methods Twenty-six steroid-naive asthmatic patients with EIB were randomized into two parallel,double-blind,cross-over study arms.Each arm compared two doses of inhaled budesonide that were administered for 3 weeks with a washout period of 3 to 8 weeks,namely(1) 100 vs 400 μg daily;and(2) 200 vs 800 μg daily.Baseline and weekly assessments with exercise challenge and sputum analysis were performed.Results Only high-dose ICS therapy(300 and 400 μg) significantly attenuated the percentage of sputum eosinophil.The percentage of sputum eosinophil was significantly correlated with EIB severity.The percentage of sputum eosinophil also predicted the magnitude and temporal response of EIB to high-dose therapy,but not to low-dose therapy(ie,100 and 200 μg).Low-dose ICS therapy significantly reduced EIB at the 1st week,with little additional improvement thereafter and irrespective of baseline sputum eosinophil counts.In contrast,a high-dose ICS therapy provided a significantly greater improvement in EIB in subjects with sputum eosinophilia compared to those with an eosinophil count of 5%.The difference was evident after the first week of high-dose ICS therapy and increased with time.Conclusion Eosinophilic airway inflammation may modify the severity of EIB and the response to ICS therapy.The percentage of sputum eosinophil may,therefore,be used in predicting the magnitude and temporal response of EIB to different dose levels of ICSs." @default.
- W2382701587 created "2016-06-24" @default.
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- W2382701587 date "2011-01-01" @default.
- W2382701587 modified "2023-09-23" @default.
- W2382701587 title "The influence of inhaled corticosteroid therapy on the enumeration of sputum eosinophils in exercise-induced asthma" @default.
- W2382701587 hasPublicationYear "2011" @default.
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