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- W2382708060 abstract "Objective To investigate the effects of oxidative stress and serum of patient with Parkinson’s disease(PD) on the mitochondrial and nuclear translocation of alpha-synuclein(α-Syn).Methods MES 23.5 dopaminergic neuronal cells were cultured in DMEM/F12 medium containing 5% fetal bovine serum.The cells were treated with H2O2 and sera from PD patients and the mitochondrial and nuclear translocations of α-syn were examined using immunofluorescent labeling.The serumal oxidative stress was evaluated by measuring with colorimetry the levels of superoxide dismutase(SOD),malondialdehyde(MDA),and total anti-oxidation competence(T-AOC) in the serum.Results Both the H2O2 and PD serum promoted the mitochondrial and nuclear translocations of α-syn,with shrank and disrupted mitochondria observed in the treated cells.The PD serum-treated cells also displayed apoptosis-like disintegrated nuclei.The levels of SOD,MDA and T-AOC were higher in PD sera than in normal sera.Conclusion Oxidative stress and PD serum promote mitochondrial and nuclear translocations of α-syn.The effect of PD serum is probably related to the increased oxidative stress." @default.
- W2382708060 created "2016-06-24" @default.
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- W2382708060 date "2010-01-01" @default.
- W2382708060 modified "2023-09-24" @default.
- W2382708060 title "H_2O_2 and Serum of Patient with Parkinson’s Disease Promote Mitochondrial and Nuclear Translocation of Alpha-synuclein" @default.
- W2382708060 hasPublicationYear "2010" @default.
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