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- W2382788630 abstract "Objective: To observe the effect of Huoxuejiedu formula on vascular endothelial growth factor(VEGF) in retina of diabetic rats,and explore the mechanism of Chines Medicine on diabetic retinopathy.Methods: A single intraperitoneal injection of streptozotocin(65mg/kg) was used to induce diabetic rats.Model rats were divided into diabetes mellitus(DM) group,Huoxue Jiedu Formula groups and Doxium group.The nomal group and model group were given normal water by intragastric administrate and Huoxue Jiedu medicine groups and Doxium group were give Huoxue Jiedu Formula(0.58g/kg,0.29g/kg,0.15g/kg,167mg/kg) through intragastric administrate.All rats were sacrificed after 24 weeks.The serum VEGF levels were measured.Immunological histochemistry assay was used to observe the express of VEGF.The expressive abundance of VEGFmRNA in rats' retina was detected by real-time quantitative PCR.Results: The level of VEGF in serum,the retinal VEGF protein expression and VEGF?mRNA were significantly higher in DM rats than in control group(P0.01).The level of VEGF in serum of Huoxuejiedu formula groups were lower than those in model group.Compared with the model group,the expression of VEGF in Huoxuejiedu formula groups decreased evidently(P0.01) and the expression of VEGFmRNA were lower than those in model groups(P0.01).Conclusion: Huoxue Jiedu Formula medicine can inhibit the expression of VEGF in retina of diabetic rats,so to inhibit the formation of new vessels and protect the tissue in diabetic retinopathy." @default.
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- W2382788630 date "2012-01-01" @default.
- W2382788630 modified "2023-09-23" @default.
- W2382788630 title "Effect of Huoxue Jiedu Formula on vascular endothelial growth factor in retina of diabetic rats" @default.
- W2382788630 hasPublicationYear "2012" @default.
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