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- W2382803921 abstract "Objective To investigate the mechanism of the anti-inflammatory effects of the chloroform eluting parts from Acanthopanax giraldii Harms Extract.Methods RAW264.7 cells were stimulated by LPS.The chloroform eluting parts were added to incubate for 20 hours.PGE 2,TNF-α and IL-10 in the supernatants were detected by RIA or Enzyme Line Immunity Assay.NO in the supernatants was detected by Greiss regent kit.Results PGE 2 production were(79.57±12.50) pg/mL and(95.20±11.20) pg/mL in the group of the chloroform eluting parts(40mg/L) and in the dosage group(10 mg/L).The chloroform eluting parts inhibited the up-regulation of LPS-induced PGE2 production(P 0.05).TNF-α production were(291.6±40.7) pg/mL and(358.6±37.9) pg/mL in the dosage group(40 mg/L or 10 mg/L).The chloroform eluting parts inhibited the up-regulation of LPS-induced TNF-α production(P 0.01).There were no difference between the group stimulated by LPS and the group of the chloroform eluting parts(P 0.05).NO production were(26.2±2.9)μmol/L and(28.3±3.2) μmol/L in the dosage group(40 mg/L or 10 mg/L).The chloroform eluting parts inhibited the up-regulation of LPS-induced NO production(P 0.01).Conclusion The mechanism of anti-inflammatory effects of Acanthopanax giraldii Harms were to inhibit the activity of COX-2 directly and the production of TNF-α and NO in inflammatory cell,but there was no effect to inhibit the production of IL-10." @default.
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- W2382803921 date "2012-01-01" @default.
- W2382803921 modified "2023-09-23" @default.
- W2382803921 title "Anti-inflammatory mechanism of the Acanthopanax giraldii Harms extract" @default.
- W2382803921 hasPublicationYear "2012" @default.
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