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- W2382807841 abstract "Objective:To observe the variation of 8-oxo-dGTPase expression and telomere length of human peripheral blood lymphocytes caused by oxidative stress and to evaluate the effect of oxidative stress in telomere length. Methods:Human lymphocytes were cultured in vitro and divided into three groups:oxidative, anti-oxidative using Vit. C and normal control group. RT-PCR were applied to study the mRNA expression of 8-oxo-dGTPase and southern hybridizing were applied to determine telomere length. Results:①The expression of 8-oxo-dGTPase was increased significantly in lymphocytes damaged by H2O2 and there was no significant difference between anti-oxidative and normal control group. ②Telomere length was shorten with the change of time. All the three groups had significant difference(P 0.01). Conclusion:①The expression of 8-oxo-dGTPase was increased significantly with increasing levels of DNA damage, and pre-treatment of cells with Vit.C can inhibit the expression of 8-oxo-dGTPase induced by oxidative stress; ②Pre-treatment of lymphocytes with Vit.C can slow the rate of telomere shortening; ③Oxidative stress takes some reaction on telomere shortening." @default.
- W2382807841 created "2016-06-24" @default.
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- W2382807841 date "2005-01-01" @default.
- W2382807841 modified "2023-09-23" @default.
- W2382807841 title "Effect on expression of 8-oxo-dGTPase and the variation of telomere length in human lymphocytes mediated by oxidative stress" @default.
- W2382807841 hasPublicationYear "2005" @default.
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