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- W2382808501 abstract "Objective To evaluate the humoral immunity induced by HBV DNA vaccine in healthy mice. Method Two eukaryotic expressed plasmids namely pS 2.S and pFP, encoding HBV middle protein(preS 2+S) or cytokine fusion protein by genetic recombinant technique and immunized the healthy mice by direct intramuscular injection. Results In the healthy C57BL/6 mice, serum anti HBs appeared at the 2 nd week after DNA vaccination, and quantitative comparison of the serum Ab level revealed a significant( P 0.05 ) or very significant( P 0.01) difference between the high dose group(82.9±30.0) mIU/ml and the median dose(42.2±25.6) mIU/ml or the lower dose (24.6±7.5) mIU/ml respectively. During the long term follow up, the difference between the high and median dose group became less remarkable, whereas it remained to be very significant as they compared with the lower dose group. Co delivery of pFP(10 μg/mice) with pS 2.S(10 μg/mice) resulted in an Ab positive rate of 100%, with its serum anti HBs level of 115.6±21.6 mIU/ml at the 2 nd week, which is significantly higher than that (21.0±7.17) mIU/ml of the control (pS 2.S+pcDNA3.1). Conclusion The plasmids we constructed are effective to induce humoral immune response in healthy mice and codelivery of cytokine fusion protein may enhance the immunity of the HBV DNA vaccine." @default.
- W2382808501 created "2016-06-24" @default.
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- W2382808501 date "2001-01-01" @default.
- W2382808501 modified "2023-09-23" @default.
- W2382808501 title "Humoral immune response induced by HBV DNA vaccine in healthy mice" @default.
- W2382808501 hasPublicationYear "2001" @default.
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