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- W2382809809 abstract "Objective To evaluate the efficacy of cyclosporine A (CsA) plus prednisone in the treatment of refractory nephrotic syndrome (RNS) in children.Methods In this retrospective analysis of the therapy of CsA (2 ~ 5 mg /(kg·d)) plus prednisone,27 cases,14 cases of steroid-resistant NS,6 cases of steroid-dependent NS and 7 cases of frequent relapse NS were included.In 25 cases of renal biopsies,15 had minimal change nephropathy,4 had focal segmental sclerosis glomerulonephritis,4 had mesangial proliferative glomerulonephritis and 2 had mesangial proliferative glomerulonephritis.Results Cyclosporine A was received for a period of 6 to 24 months (mean 11.6 ± 6.6 mos).CsA induced complete remission in 16 cases,partial remission in 9 cases and invalid in 2 cases.The total remission rate was 88.9%.The response to CsA was no significant differences in SRNS,SDNS and FRNS.Different renal pathological types did not effect the response.The rate of complete remission was significantly higher in patients with cholesterin level less than 9.0 mmol /L as compared with those with cholesterin level more than 9.0 mmol /L.The main adverse effects of CsA included hirsutism,mild hypertension,mild liver function impairment,creatinine increase,gingival enlargement etc,and all were acceptable.Conclusions CsA combined with prednisone is effective and safe in the treatment of children with RNS." @default.
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- W2382809809 date "2010-01-01" @default.
- W2382809809 modified "2023-09-26" @default.
- W2382809809 title "The effects of cyclosporine A in children with refractory nephrotic syndrome" @default.
- W2382809809 hasPublicationYear "2010" @default.
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