Matches in SemOpenAlex for { <https://semopenalex.org/work/W2382811355> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2382811355 endingPage "70" @default.
- W2382811355 startingPage "63" @default.
- W2382811355 abstract "We have been studying the mechanisms involved in the oxidative modification of low density lipoprotein (LDL) that lead to its transformation to a cytotoxic complex. Here we examine the direct effect-of soybean lipoxygenase (SLO), a 15-lipoxygenase, on normal human LDL. SLO oxidized LDL and rendered it cytotoxic; agents known to interfere with lipoxygenase activity inhibited this reaction. Enhancement of both the SLO-mediated LDL oxidation and the conversion of LDL to a cytotoxin was observed when either superoxide dismutase or copper (II) (3,5,-diisopropylsalicylic acid)2, both of which dismute superoxide anion, were included during the incubation of SLO with LDL. In contrast, catalase inhibited this reaction in the presence or absence of agents that dismute superoxide anion. Thus, purified lipoxygenase can mediate LDL modification and superoxide anion inhibits this reaction, Furthermore, H2O2 is essential for SLO-mediated LDL oxidation and conversion of LDL to a cytotoxin." @default.
- W2382811355 created "2016-06-24" @default.
- W2382811355 creator A5001688151 @default.
- W2382811355 creator A5019920561 @default.
- W2382811355 creator A5026274442 @default.
- W2382811355 date "1991-01-01" @default.
- W2382811355 modified "2023-09-24" @default.
- W2382811355 title "Lipoxygenase-mediated transformation of human low density lipoprotein to an oxidized and cytotoxic complex." @default.
- W2382811355 cites W1871621847 @default.
- W2382811355 cites W1925566386 @default.
- W2382811355 cites W1971097020 @default.
- W2382811355 cites W2005182309 @default.
- W2382811355 cites W2005230846 @default.
- W2382811355 cites W2011383364 @default.
- W2382811355 cites W2014751729 @default.
- W2382811355 cites W2064484362 @default.
- W2382811355 cites W2066342792 @default.
- W2382811355 cites W2066407962 @default.
- W2382811355 cites W2070951814 @default.
- W2382811355 cites W2086605115 @default.
- W2382811355 cites W2090036631 @default.
- W2382811355 cites W2091622651 @default.
- W2382811355 cites W2109068111 @default.
- W2382811355 cites W2117909173 @default.
- W2382811355 cites W2121972309 @default.
- W2382811355 cites W2161188230 @default.
- W2382811355 cites W2168526937 @default.
- W2382811355 cites W2170583921 @default.
- W2382811355 cites W2183817340 @default.
- W2382811355 cites W2300552860 @default.
- W2382811355 cites W2481467100 @default.
- W2382811355 cites W4250693163 @default.
- W2382811355 doi "https://doi.org/10.1016/s0022-2275(20)42244-8" @default.
- W2382811355 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1901344" @default.
- W2382811355 hasPublicationYear "1991" @default.
- W2382811355 type Work @default.
- W2382811355 sameAs 2382811355 @default.
- W2382811355 citedByCount "115" @default.
- W2382811355 countsByYear W23828113552012 @default.
- W2382811355 countsByYear W23828113552013 @default.
- W2382811355 countsByYear W23828113552014 @default.
- W2382811355 countsByYear W23828113552015 @default.
- W2382811355 countsByYear W23828113552016 @default.
- W2382811355 countsByYear W23828113552017 @default.
- W2382811355 countsByYear W23828113552019 @default.
- W2382811355 countsByYear W23828113552021 @default.
- W2382811355 countsByYear W23828113552023 @default.
- W2382811355 crossrefType "journal-article" @default.
- W2382811355 hasAuthorship W2382811355A5001688151 @default.
- W2382811355 hasAuthorship W2382811355A5019920561 @default.
- W2382811355 hasAuthorship W2382811355A5026274442 @default.
- W2382811355 hasBestOaLocation W23828113551 @default.
- W2382811355 hasConcept C104317684 @default.
- W2382811355 hasConcept C154317977 @default.
- W2382811355 hasConcept C185592680 @default.
- W2382811355 hasConcept C202751555 @default.
- W2382811355 hasConcept C204241405 @default.
- W2382811355 hasConcept C2778163477 @default.
- W2382811355 hasConcept C2779620165 @default.
- W2382811355 hasConcept C55493867 @default.
- W2382811355 hasConcept C86803240 @default.
- W2382811355 hasConcept C95444343 @default.
- W2382811355 hasConceptScore W2382811355C104317684 @default.
- W2382811355 hasConceptScore W2382811355C154317977 @default.
- W2382811355 hasConceptScore W2382811355C185592680 @default.
- W2382811355 hasConceptScore W2382811355C202751555 @default.
- W2382811355 hasConceptScore W2382811355C204241405 @default.
- W2382811355 hasConceptScore W2382811355C2778163477 @default.
- W2382811355 hasConceptScore W2382811355C2779620165 @default.
- W2382811355 hasConceptScore W2382811355C55493867 @default.
- W2382811355 hasConceptScore W2382811355C86803240 @default.
- W2382811355 hasConceptScore W2382811355C95444343 @default.
- W2382811355 hasIssue "1" @default.
- W2382811355 hasLocation W23828113551 @default.
- W2382811355 hasOpenAccess W2382811355 @default.
- W2382811355 hasPrimaryLocation W23828113551 @default.
- W2382811355 hasRelatedWork W1654802422 @default.
- W2382811355 hasRelatedWork W1871621847 @default.
- W2382811355 hasRelatedWork W1966874554 @default.
- W2382811355 hasRelatedWork W2035905848 @default.
- W2382811355 hasRelatedWork W2057191558 @default.
- W2382811355 hasRelatedWork W2065910898 @default.
- W2382811355 hasRelatedWork W2088110055 @default.
- W2382811355 hasRelatedWork W2157710105 @default.
- W2382811355 hasRelatedWork W2323622976 @default.
- W2382811355 hasRelatedWork W2407132424 @default.
- W2382811355 hasVolume "32" @default.
- W2382811355 isParatext "false" @default.
- W2382811355 isRetracted "false" @default.
- W2382811355 magId "2382811355" @default.
- W2382811355 workType "article" @default.