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- W2382829403 abstract "[Objective] The aim of the research was to lay the foundation for producing the vaccine of avian infectious bronchitis(AIB) vaccine.[Method] Based on studying the virulence,immunogenicity and preservation period of the used virus seed for preparing AIB vaccines,50% egg infective dose of strain M41 of infectious bronchitis(IB) from 4 kinds of resources were determined.The virus with higher titer was taken as virus seed to establish the seed batches of strain M41 of IB and its virulence was determined.[Result] The virulence of allantoic fluid with the virus didn't change before and after freeze drying.The results of virulence test showed that the virulence of the virus was medium and it could provide protection for chicken.The EID50 value and immunogenicity of strain M41 of seed virus had no change in 7 generations.When the damp-toxin was preserved at-15℃ within half a year,its toxic value was essentially constant.The established seed batches were not polluted by bacteria and other microbe.[Conclusion] The seed batches could be used for producing AIB." @default.
- W2382829403 created "2016-06-24" @default.
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- W2382829403 date "2008-01-01" @default.
- W2382829403 modified "2023-09-23" @default.
- W2382829403 title "Establishment of Seed Batches of Strain M41 of Infectious Bronchitis Virus" @default.
- W2382829403 hasPublicationYear "2008" @default.
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