Matches in SemOpenAlex for { <https://semopenalex.org/work/W2382832357> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2382832357 endingPage "1529" @default.
- W2382832357 startingPage "1526" @default.
- W2382832357 abstract "Objective To make a comparison between the antitumor effect and the chemical constituents of Huanglian Jiedu decoction (HLJDT) and that of serum containing HLJDT. Method Based on the established chromatographic fingerprint of HLJDT, analysis and comparison were made between the HPLC fingerprints of rat serum samples obtained after orally taking HLJDT and those of control rat serum samples. The different effects on NCI-H446 and Bel-74024 cancer cells from human were investigated in vitro using HLJDT and its serum. The inhibitory effects of HLJDT and its serum were observed by MTT assay. Result Ten compounds of HLJDT and some metabolites were detected after oral administration of HLJDT, and however some main compounds of HLJDT were not detected in serum. Both HLJDT and its serum in different dosage groups could inhibit the proliferation of NCI-H446 and Bel-7402 cancer cells from human in a dose-dependent manner, but inhibitory grade was different in the two cancer cell lines. HLJDT had more inhibitory effect on Bel-7402 than on NCI-H446, on the other hand serum containing HLJDT had the same inhibitory effect on Bel-7402 and NCI-H446. Conclusion The reason for inhibitory grade change was that the proportion of concentration of many compounds in serum containing HLJDT was different to that in HLJDT, which should be subject to thorough investigation so as to illuminate the pharmacology and active mechanism of HLJDT." @default.
- W2382832357 created "2016-06-24" @default.
- W2382832357 creator A5000223092 @default.
- W2382832357 creator A5007024868 @default.
- W2382832357 creator A5025110155 @default.
- W2382832357 creator A5041659230 @default.
- W2382832357 creator A5042877654 @default.
- W2382832357 creator A5077898454 @default.
- W2382832357 creator A5083976719 @default.
- W2382832357 date "2006-09-01" @default.
- W2382832357 modified "2023-10-12" @default.
- W2382832357 title "Comparison between antitumor effect and chemical constituents of Huanglian Jiedu decoction and that of serum containing Huanglian Jiedu decoction" @default.
- W2382832357 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17144472" @default.
- W2382832357 hasPublicationYear "2006" @default.
- W2382832357 type Work @default.
- W2382832357 sameAs 2382832357 @default.
- W2382832357 citedByCount "2" @default.
- W2382832357 countsByYear W23828323572016 @default.
- W2382832357 countsByYear W23828323572018 @default.
- W2382832357 crossrefType "journal-article" @default.
- W2382832357 hasAuthorship W2382832357A5000223092 @default.
- W2382832357 hasAuthorship W2382832357A5007024868 @default.
- W2382832357 hasAuthorship W2382832357A5025110155 @default.
- W2382832357 hasAuthorship W2382832357A5041659230 @default.
- W2382832357 hasAuthorship W2382832357A5042877654 @default.
- W2382832357 hasAuthorship W2382832357A5077898454 @default.
- W2382832357 hasAuthorship W2382832357A5083976719 @default.
- W2382832357 hasConcept C185592680 @default.
- W2382832357 hasConcept C190409667 @default.
- W2382832357 hasConcept C556039675 @default.
- W2382832357 hasConcept C71924100 @default.
- W2382832357 hasConcept C98274493 @default.
- W2382832357 hasConceptScore W2382832357C185592680 @default.
- W2382832357 hasConceptScore W2382832357C190409667 @default.
- W2382832357 hasConceptScore W2382832357C556039675 @default.
- W2382832357 hasConceptScore W2382832357C71924100 @default.
- W2382832357 hasConceptScore W2382832357C98274493 @default.
- W2382832357 hasIssue "18" @default.
- W2382832357 hasLocation W23828323571 @default.
- W2382832357 hasLocation W23828323572 @default.
- W2382832357 hasOpenAccess W2382832357 @default.
- W2382832357 hasPrimaryLocation W23828323571 @default.
- W2382832357 hasRelatedWork W1523554578 @default.
- W2382832357 hasRelatedWork W2039987276 @default.
- W2382832357 hasRelatedWork W2058265794 @default.
- W2382832357 hasRelatedWork W2325920803 @default.
- W2382832357 hasRelatedWork W2329422055 @default.
- W2382832357 hasRelatedWork W2335194339 @default.
- W2382832357 hasRelatedWork W2348556107 @default.
- W2382832357 hasRelatedWork W2350487730 @default.
- W2382832357 hasRelatedWork W2354091381 @default.
- W2382832357 hasRelatedWork W2362717655 @default.
- W2382832357 hasRelatedWork W2369460551 @default.
- W2382832357 hasRelatedWork W2369977922 @default.
- W2382832357 hasRelatedWork W2371070626 @default.
- W2382832357 hasRelatedWork W2373990440 @default.
- W2382832357 hasRelatedWork W2383693434 @default.
- W2382832357 hasRelatedWork W2389132571 @default.
- W2382832357 hasRelatedWork W2394510019 @default.
- W2382832357 hasRelatedWork W2464478084 @default.
- W2382832357 hasRelatedWork W2620537658 @default.
- W2382832357 hasRelatedWork W3131932867 @default.
- W2382832357 hasVolume "31" @default.
- W2382832357 isParatext "false" @default.
- W2382832357 isRetracted "false" @default.
- W2382832357 magId "2382832357" @default.
- W2382832357 workType "article" @default.