Matches in SemOpenAlex for { <https://semopenalex.org/work/W2382833544> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W2382833544 abstract "Vitamin A (all-trans-retinol) or its derivatives are involved in many physiological processes ranging from vision to cells differentiation. In mammals retinol is stored as retinyl ester (RE) and the liver is the major site for RE storage in the body. The liver is made of various cell types and REs are predominantly stored in hepatic stellate cells (HSCs). Under physiological conditions these cells play an important role in vitamin A homeostasis. One important characteristics of HSCs are their RE rich lipid droplets (LDs). In fact approximately 35% of the neutral lipid core of this droplet is RE, a percentage which strongly depends on the amount of dietary vitamin A. Under pathological conditions, like hepatic fibrosis, HSCs undergo both metabolic and morphological changes. The morphology of HSCs changes from a star-shaped stellate cell to that of a (myo-) fibroblast. During this trans-differentiation the HSCs lose their vitamin A-rich lipid droplets and start synthesizing extracellular matrix components. In this dissertation various enzymes and metabolic pathways related to REs storage was studied in cell lines and transgenic mice. Advance technique in lipidomics was adapted in this dissertation to elucidate the LD dynamics in HSCs in relation to Vitamin A storage metabolism." @default.
- W2382833544 created "2016-06-24" @default.
- W2382833544 creator A5035743333 @default.
- W2382833544 date "2015-12-17" @default.
- W2382833544 modified "2023-09-24" @default.
- W2382833544 title "Retinol metabolism in hepatic stellate cells : a new vision" @default.
- W2382833544 hasPublicationYear "2015" @default.
- W2382833544 type Work @default.
- W2382833544 sameAs 2382833544 @default.
- W2382833544 citedByCount "0" @default.
- W2382833544 crossrefType "dissertation" @default.
- W2382833544 hasAuthorship W2382833544A5035743333 @default.
- W2382833544 hasConcept C134018914 @default.
- W2382833544 hasConcept C176891718 @default.
- W2382833544 hasConcept C185592680 @default.
- W2382833544 hasConcept C189165786 @default.
- W2382833544 hasConcept C25095133 @default.
- W2382833544 hasConcept C2776940978 @default.
- W2382833544 hasConcept C2779573558 @default.
- W2382833544 hasConcept C4733338 @default.
- W2382833544 hasConcept C55493867 @default.
- W2382833544 hasConcept C86803240 @default.
- W2382833544 hasConcept C95444343 @default.
- W2382833544 hasConceptScore W2382833544C134018914 @default.
- W2382833544 hasConceptScore W2382833544C176891718 @default.
- W2382833544 hasConceptScore W2382833544C185592680 @default.
- W2382833544 hasConceptScore W2382833544C189165786 @default.
- W2382833544 hasConceptScore W2382833544C25095133 @default.
- W2382833544 hasConceptScore W2382833544C2776940978 @default.
- W2382833544 hasConceptScore W2382833544C2779573558 @default.
- W2382833544 hasConceptScore W2382833544C4733338 @default.
- W2382833544 hasConceptScore W2382833544C55493867 @default.
- W2382833544 hasConceptScore W2382833544C86803240 @default.
- W2382833544 hasConceptScore W2382833544C95444343 @default.
- W2382833544 hasLocation W23828335441 @default.
- W2382833544 hasOpenAccess W2382833544 @default.
- W2382833544 hasPrimaryLocation W23828335441 @default.
- W2382833544 hasRelatedWork W1444341731 @default.
- W2382833544 hasRelatedWork W149790328 @default.
- W2382833544 hasRelatedWork W1516756689 @default.
- W2382833544 hasRelatedWork W1538483334 @default.
- W2382833544 hasRelatedWork W1981293446 @default.
- W2382833544 hasRelatedWork W2038802704 @default.
- W2382833544 hasRelatedWork W2045116750 @default.
- W2382833544 hasRelatedWork W2083480859 @default.
- W2382833544 hasRelatedWork W2092602627 @default.
- W2382833544 hasRelatedWork W2104187605 @default.
- W2382833544 hasRelatedWork W2105482874 @default.
- W2382833544 hasRelatedWork W2171936039 @default.
- W2382833544 hasRelatedWork W2254177481 @default.
- W2382833544 hasRelatedWork W2485342729 @default.
- W2382833544 hasRelatedWork W2772059796 @default.
- W2382833544 hasRelatedWork W2884852672 @default.
- W2382833544 hasRelatedWork W2938810076 @default.
- W2382833544 hasRelatedWork W3115486857 @default.
- W2382833544 hasRelatedWork W3145732138 @default.
- W2382833544 hasRelatedWork W2461375058 @default.
- W2382833544 isParatext "false" @default.
- W2382833544 isRetracted "false" @default.
- W2382833544 magId "2382833544" @default.
- W2382833544 workType "dissertation" @default.