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- W2382839757 abstract "Objective: To establish a method for the determination of acemetacin and indometacin concentrations in rabbits plasma. Method: HPLC method was adopted. Ketoprofen was used as the internal standard,Hypersil BDS C18( 4.6 mm×250mm,5μm) column was used,the mobile phase consisted pH4.5acetate buffer solution-acetonitrile-methanol( 50 ∶ 40 ∶ 10),flow rate was 0.6mL / min,column temperature was 25℃,the detection wave length was 250nm,injection volume was 20μL. Result: The linear range of acemetacin was 0.04-2.56μg / mL,the average recovery was 89.4%,RSD = 5.2%( n = 5); The linear range of indometacin was 0.03-1.92μg / mL,the average recovery was 89.7%,RSD = 5.7%( n = 5). Conclusion: The method is simple,sensitive and accurate,and it can be applied to the determination of acemetacin and indometacin concentrations in rabbits plasma." @default.
- W2382839757 created "2016-06-24" @default.
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- W2382839757 date "2014-01-01" @default.
- W2382839757 modified "2023-09-27" @default.
- W2382839757 title "Determination of Acemetacin and Indometacin in Rabbits Plasma by HPLC" @default.
- W2382839757 hasPublicationYear "2014" @default.
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