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- W2382842885 abstract "Objective To monitor the inflammatory marks of Procalcitonin (PCT) and C-reaction (CRP) in peadiatric patients with major β-thalassaemia scheduled for allogenetic hemopoietic stem cell transplantation during conditioning with anti-thymocyte globulin (ATG).Methods Twenty-five children with majorβ-thalassaemia were enrolled.ATG was administrated for conditioning before transplantation.Baseline PCT,CRP,white blood cell count,liver function and serum ferroprotein were assessed before conditioning.CRP and white blood cell count were assessed daily,while PCT and liver function were assessed alternate days for one week.Results Baseline levels (BL) of both PCT and CRP before ATG administration were within normal range (PCT0.5 ug/L,CRP5 mg/L).Significant increase of PCT and CRP was observed on 1st day (P0.01) and regressed to baseline level between 4th and 6th day.No significant correlation between PCT or CRP level and liver functions or serum ferritin levels (P0.05).Conclusion ATG administration usually triggers a febrile response and is associateds with a characteristic rapid surge of Procalcitonin (PCT) and C-reaction (CRP).Since the increase of PCT or CRP is not associated with systemic infection,no diagnostic significance for infection is provided by PCT and CRP.PCT and CRP levels are not correlated with liver functions,WBC count or ferroprotein levels." @default.
- W2382842885 created "2016-06-24" @default.
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- W2382842885 date "2010-01-01" @default.
- W2382842885 modified "2023-09-28" @default.
- W2382842885 title "Procalcitonin and C-reactive protein changes during pretreatment of anti-thymocyte globulin before hematopoietic stem cell transplantation in pediatric patients" @default.
- W2382842885 hasPublicationYear "2010" @default.
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