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- W2382847012 abstract "AIM: To investigate the effect of cholestane-3β,5α,6β-triol(Triol) on apoptosis of malignant glioma cells.METHODS: C6 cells and A172 cells were incubated with Triol at different concentrations for different time durations.MTT assay was used to detect the cell viability.Hoechst 3f3342 staining and TUNEL assay were used to analyze the cell apoptosis.The caspase activity was measured.The expression of apoptosis-related proteins,Bcl-2 family members,was determined by Western blotting.RESULTS: Triol decreased the cell viability of C6 and A172 cells in a dose-and time-dependent manner and the IC50 values were(17.8±0.6)μmol/L and(20.6±0.2) μmol/L,respectively.Visible nuclei with apoptotic characteristics,significant increase in TUNEL-positive cells,and the activation of apoptotic execution enzyme caspase-3 indicated that cell apoptosis was induced by Triol in both cell lines.After C6 cells were exposed to Triol for 12 h,24 h and 48 h,the activity of caspase-8 in extrinsic apoptotic pathway and caspase-9 in intrinsic apoptotic pathway was increased time-dependently.Meanwhile,the levels of anti-apoptotic proteins,Bcl-2 and Bcl-xL,was down-regulated,while pro-apoptotic protein Bak was up-regulated in a time-dependent manner.CONCLUSION: Triol induces apoptosis of malignant glioma cells by activating intrinsic and extrinsic apoptotic pathways,and Bcl-2 family members are involved in Triol-induced apoptosis." @default.
- W2382847012 created "2016-06-24" @default.
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- W2382847012 date "2013-01-01" @default.
- W2382847012 modified "2023-09-24" @default.
- W2382847012 title "Cholestane-3β,5α,6β-triol induces apoptosis of malignant glioma cells" @default.
- W2382847012 hasPublicationYear "2013" @default.
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