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- W2382848163 abstract "Mice inoculated with Ehrlich ascites carcinoma cells were intraperitoneally injected on the 8th day with actinomycin K. The animals were killed 6 hours after injection.At the dosage of 400μg/kg body weight, the amounts of acid-soluble P, inorganic P, fat-soluble P, nucleoprotein-nitrogen and DNA on the basis of the dry weight or of the number of carcinoma cells remained unaffected, but the amount of RNA decreased(not at the therapeutic dose of 50μg/kg).Starting from the 3rd day after inoculation actinomycin K was given daily at the dosage of 50μg/kg for 5 consecutive days. Six hours after the last injection the mice were killed. Both the amounts of RNA and nucleoprotein-nitrogen, on the basis of cell number, were decreased. If the dry weight was used as the basis for comparison, the amount of RNA still showed marked reduction but that of nucleoprotein-nitrogen did not differ significantly. On the other hand, the amount of DNA per mg dry weight increased.Na_2HP~(32)O_4 was injected subcutaneously at the dosage of 1μc/g body weight, 2 hours following the injection of actinomycin K. Four hours after the administration of the isotope, the specific radio activities(cpm/μg P) of the acid-soluble P and the inorganic P in the carcinoma cells of the treated mice were similar to those of the controls. But the specific radioactivity of RNA decreased: at the dosage of 50μg/kg the degree of inhibition was 40%, and at the dosage of 400μg/kg, 52%.From these experimental data, it may be concluded that the synthesis of RNA in the carcinoma cells is more affected by actinomycin K than those of protein or DNA." @default.
- W2382848163 created "2016-06-24" @default.
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- W2382848163 date "1962-01-01" @default.
- W2382848163 modified "2023-09-25" @default.
- W2382848163 title "STUDIES ON ANTITUMOR DRUGS XII. EFFECT OF ACTINOMYCIN K ON THE AMOUNT OF AND ON THE INCORPORATION OF P~(32) INTO NUCLEIC ACIDS OF EHRLICH CARCINOMA CELLS" @default.
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