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- W2382864968 abstract "Objective To analyze the significance of heat shock protein 47(HSP47) gene in keloid formation by the in vivo intervention with RNAi technology and the recombinant plasmid of HSP47 siRNA against HSP47 in nude mice keloid model.Methods RNAi mixture(0.25 ml) was injected into the keloid in experiment group and PBS(0.25 ml) was injected into the keloid in control group on the 16th day after the models were established.Following in vivo intervention,the specimens were observed and harvested on the 7th day for determination of mRNA and collagen levels and immunohistochemical staining.Results After in vivo intervention,the expression of HSP47 gene remarkably decreased in contrast to the control group(P0.01),and the expression of collagen was markedly lower than the control group(P0.01).Conclusion The expression of HSP47 gene promotes the formation of keloid,which provides a new target to treatment of keloid." @default.
- W2382864968 created "2016-06-24" @default.
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- W2382864968 date "2008-01-01" @default.
- W2382864968 modified "2023-09-26" @default.
- W2382864968 title "The in vivo intervention by the recombinant plasmid of HSP47 siRNA against nude mice keloid model" @default.
- W2382864968 hasPublicationYear "2008" @default.
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