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- W2382866947 abstract "Objective To explore the inhibitory effect of bevacizumab,a kind of vascular endothelial growth factor antibody,and bevacizumab combined with radiotherapy on against angiogenesis in osteosarcoma of nude mice.Methods Sixteen nude mice inoculated with human osteosarcoma cell line 9901 were randomly divided into four groups:bevacizumab group(only treated with bevacizumab 2mg/kg,once a week for two weeks),radiotherapy group(5 Gy per week,twice),combined treatment group(treated with bevacizumab and radiotherapy) and control group(injected with saline solution).Long and short diameters of the tumors were measured and the volume was calculated during treatment.The tumor inhibition rate(TIR) was calculated on the day 13 after treatment.Meanwhile the microvessel density(MVD),necrosis,proliferation index(PI) and apoptotic index(AI) were observed pathologically by immunohistochemical staining.Results The TIRs were 32.87%,26.39% and 87.50%(P0.01),and the necrotic proportion was 11.49%±0.20%,10.30%±0.12% and 27.15%±1.08%(P0.01) in bevacizumab group,radiotherapy group and combination treatment group,respectively.The MVD and PI were significantly higher,while AI was remarkably lower in control group than in the other groups(P0.01),while the MVD and PI were significantly lower and PI was remarkably higher in combined treatment group than in both bevacizumab group and radiotherapy group(P0.01).Conclusions Bevacizumab may remarkably inhibit the osteosarcoma angiogenesis and tumor cell proliferation,induce apoptosis,and has a potential synergistic action with radiotherapy in antiangiogenesis." @default.
- W2382866947 created "2016-06-24" @default.
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- W2382866947 date "2009-01-01" @default.
- W2382866947 modified "2023-09-23" @default.
- W2382866947 title "Studies on the inhibitory effect of bevacizumab on angiogenesis in osteosarcoma and the synergetic effcet of bevacizumab with radiotherapy in nude mice" @default.
- W2382866947 hasPublicationYear "2009" @default.
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