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- W2382868589 abstract "Objective To study the release rate of metformin hydrochloride sustained-release tablets in vitro by different manufacturers, in order to provide the basis for clinical rational drug use. Methods According to the standard of metformin hydrochloride sustainedrelease tablets( imported drug registration standard JX20010451) and related references,the stripping device of rotating basket method was adopted for the release experiment in vitro. Phosphate buffer solution 1 000 mL with pH 6. 8 was used as medium,at 100 rpm rotation speed,and the temperature was at( 37 ± 0. 5) ℃. The content was determined by UV spectrophotometry. In vitro release tests of metformin hydrochloride sustained-release tablets of different manufacturers were taken and the cumulative release percentage,drawing stripping curve and f2similarity factor were calculated. Results The f2similarity factor of two kinds of imported preparation was 93. 54. The f2similarity factors of the domestic preparation and Bristol-Myers Squibb formulation were 47. 80,48. 10,49. 67,66. 27, 47. 65,70. 53,67. 05,respectively; and the f2similarity factors of the domestic preparation and BIOVAIL formulation are 49. 21, 49. 49,51. 25,67. 00,49. 05,68. 22,67. 21,respectively. Conclusions The domestic and imported preparations have significant differences in drug release behavior in vitro." @default.
- W2382868589 created "2016-06-24" @default.
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- W2382868589 date "2014-01-01" @default.
- W2382868589 modified "2023-09-24" @default.
- W2382868589 title "Release of metformin hydrochloride sustained-release tablets in vitro by different manufacturers" @default.
- W2382868589 hasPublicationYear "2014" @default.
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