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- W2382871621 abstract "Objective To investigate the effect of platelet-activating factor acetylhydrolase(PAF-AH) on(severe) acute pancreatitis(SAP).Methods Forty-five male Wistar rats were randomly divided into three groups(n=15 in each group),including group A(sham operation group),group B(SAP group) and group C(PAF-AH treated group).PAF-AH(5mg/kg) was infused through the dorsal artery of penis after 1 hour and 24 hours of establishing the model in group C.Forty-eight hours after animal models were established,the levels of maleic dialdehyde(MDA),thromboxane B2(TXB_2),prostaglandin I2(PGI_2),TXB_2/PGI_2,(platelet)-activating factor(PAF),endotoxin,tumor necrosis factor(TNF-α) in serum,and the activity of(myeloperoxidase)(MPO) in lung tissue were examined in each group.The pancreas was scored on the basis of pathological changes.Results Compared with group B,the levels of MDA,TXB_2,TXB_2/PGI_2,PAF,(endotoxin),TNF-α in serum,and MPO activity in lung tissue and the pathological scores of pancreas were(significantly) lower in group C(P0.05).There was no obvious difference in the level of PGI_2 between group B and group C(P0.05).Conclusions PAF plays a critical role during the course of SAP.(Administration) of PAF-AH can hydrolyze PAF,improve pancreatic microcirculatory dysfunction,suppress(systemic) inflammatory reaction,relieve pancreatitis-associated intestinal tract injury and lung injury and(markedly) ameliorate the state of SAP." @default.
- W2382871621 created "2016-06-24" @default.
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- W2382871621 date "2005-01-01" @default.
- W2382871621 modified "2023-09-23" @default.
- W2382871621 title "Experimental study of the effect of platelet-activating factor acetylhydrolase on severe acute pancreatitis" @default.
- W2382871621 hasPublicationYear "2005" @default.
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