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- W2382871836 abstract "Objective:To observe the effect of Zhengganfang(ZGF) on IGF-Ⅱin rat hepatic precancerous lesion tissue.Methods:One hundred wistar rats were divided into four groups:control group of model,group of ZGF low dosage,group of ZGF high dosage and control group of normal rats.Except the control group of normal rats,all rats in each group were treated with AFB1 and 2-AAF successively for making model.During the period of making model,the rats in group of ZGF low dosage and group of ZGF high dosage were fed with ZGF at different dosage.The experiment was ended after eight weeks,and the autopsied liver tissues from each rat were checked for IGF-Ⅱ by immunohistochemistry method and RT-PCR.Results:Not only both the numeral PU and LI of IGF-Ⅱ protein,but also the expression of IGF-Ⅱ mRNA in liver tissues of model group were the highest in four group.ZGF could lessen the ablomal high expression of IGF-Ⅱ in rat hepatic precancerous lesion tissue(P0.01),and the function of lessening showed dose-effect relationship.Conclusion:ZGF has the function of down regulation of the ablomal IGF-Ⅱ expression,and therefore the paraplasm of hepatocyte stimulatied by IGF-Ⅱ autocrine slow down." @default.
- W2382871836 created "2016-06-24" @default.
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- W2382871836 date "2010-01-01" @default.
- W2382871836 modified "2023-09-25" @default.
- W2382871836 title "Effect of Zhengganfang on expression of IGF-II in rat hepatic precancerous lesion tissue induced by aflatoxin B_1" @default.
- W2382871836 hasPublicationYear "2010" @default.
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