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- W2382882014 abstract "Objective To study the related mechanism of laparoscopic adjustable gastric banding(LAGB) in treatment of type 2 diabetes mellitus(T2DM).Methods Twenty patients with obesity accompanying T2DM and 20 patients with simple obesity underwent LAGB,respectively.Levels of fasting serum leptin,fasting serum insulin,C-peptide,glycated hemoglobin(HbA1c),FBG,as well as body weight and calculating body mass index(BMI) were measured before and 1,3,6,12 months after LAGB.Results The BMI was decreased from 38±5kg/m2 before operation to 30±4kg/m2 and 28±7kg/m2 respectively,6 and 12 month after operation in the 40 patients(P0.05).The serum levels of FBG,fasting serum insulin,insulin resistance index [HOMA-IR= FINS(mU/L)×FBG(mmol/L)/22.5],HbA1c,and C-peptide preoperative levels were significantly higher in patients with T2DM than control group before operation(P0.01).The FBG levels(8.5±3.0mmol/L) were significantly lower 6 and 12 month(6.5±1.0mmol/L and 5.9±0.5mmol/L) after operation than before operation.The levels of fasting serum insulin and HbA1c returned to normal range 3 month after operation(P0.01).The serum level of leptin in two groups was gradually declined 12 month after operation.No significant correlation was found between the serum levels of leptin,FBG,fasting serum insulin,HbA1c,C-peptide,HOMA-IR.Conclusion LAGB can effectively treat obesity accompanying T2DM by reducing serum leptin levels,insulin resistance,and blood sugar level." @default.
- W2382882014 created "2016-06-24" @default.
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- W2382882014 date "2010-01-01" @default.
- W2382882014 modified "2023-09-24" @default.
- W2382882014 title "Laparoscopic adjustable gastric banding in treatment of obesity accompanying type 2 diabetes" @default.
- W2382882014 hasPublicationYear "2010" @default.
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