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- W2382884167 abstract "Objective: To investigate the deletion of p16 gene in Chinese patients non-small cell lung cancer (NSCLC) and the role of the p16 gene as a tumor suppressor gene in the genesis of chinese NSCLC. Methods: Reverse transcription polymerase chain reaction(RT-PCR) was used to detect the deletion at p16 gene exons 1-2 in 31 patients with NSCLC. Results: The deletions of p16 gene were found in 26 of 31 NSCLC(83.9%). Most pattern of p16 gene deletion was loss of heterozygosity(LOH). The deletion of p16 gene was not significanfly associated with histological type or cell differentiation, as well as metastasis and clinical stage of NSCLC. In stage I and Ⅱ NSCLC, the obvious deletion of p16 gene was examined. Conclusion: p16 gene may play importmant role in genesis and progression of NSCLC.Deletion of p16 gene may be an early event of lung cancer, and may be of importance for early diagnosis of lung cancers." @default.
- W2382884167 created "2016-06-24" @default.
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- W2382884167 date "2004-01-01" @default.
- W2382884167 modified "2023-09-25" @default.
- W2382884167 title "Studies On the Deletion of p16 Gene in Non-small Cell Lung Cancer" @default.
- W2382884167 hasPublicationYear "2004" @default.
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