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- W2382888925 abstract "Objective To study the effect of ShouCong capsule on learning and memory ability,ChAT and pathological changes of cerebra cortex in rats with Alzheimer's disease.Methods Male Wistar rats were randomly divided into 5 groups: blank control group,model group,NaoFuKang group,ShouCong capsule(low,high dose)group.Alzheimer's disease(AD) model rats were made by injection with D-galactose on the back of the neck,then injection with scopolamin in the intraperiton.Learning and memory ability of rats was evaluated with a series of tasks to find a hidden plation in dark box,the tissue pathological changes under light microscope and choline acetyltransferase(ChAT) by electron lens using immunohistochemistry method were observed.Results In low and high dose ShouCong capsule groups,the electric latent period was lengthened while 5-minute error frequency was decreased;the pathological injury of dementia rats was respectively lessened.The number of ChAT positive neurons in cerebral cortex was significantly increased compared with that in the model group(P0.01),but there was not cerebral significantly increased compared with NaoFuKang group(P0.05).Conclusion ShouCong capsule can greatly improve learning and memory capacity,lessen the pathological injury of dementia rats,and the mechanism is possibly relevant with the protection of cholinergic system,enhancment of ChAT evel to further synthesize Ach." @default.
- W2382888925 created "2016-06-24" @default.
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- W2382888925 date "2011-01-01" @default.
- W2382888925 modified "2023-09-26" @default.
- W2382888925 title "Effect of ShouCong Capsule on Learning and Memory Ability and ChAT of Cerebra Cortex in Rats with Alzheimer's Disease" @default.
- W2382888925 hasPublicationYear "2011" @default.
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