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- W2382893158 abstract "Objective To study the effects of acetylcholine(ACh) on the electric activities of pain-inhibition neurons(PIN) in caudate nucleus in one side of rat brain after intracerebroventricular(i.c.v.) injections of antagonists for muscarinic receptor subtype 1(M1),3(M3),and 4(M4).Methods Trains of the electric impulses applied to the left sciatic nerve were used as noxious stimulus,the discharge of pain-inhibition neurons was led out by extracellular recording method with the glass microelectrode in one side of rat caudate nucleus.The influence of i.c.v.injection of muscarinic receptor subtype antagonists on the noxious stimulation-evoked activities of PIN in caudate nucleus were observed.Results ①I.c.v.injection of ACh(20μg/10μL) resulted in an excitation of evoked response of PIN;②The excitatory effect on the electric discharges of PIN of ACh was partly blocked by i.c.v.administration of M1 receptor antagonist pirenzepine at the dose of 10μg/10μL.M3 receptor antagonist 4-DAMP and M4 receptor antagonist tropicamide could not block the effect of ACh.Conclusion ACh plays an inhibitory role in regulating pain.M1 receptor was mainly involved in this analgesia mechanism." @default.
- W2382893158 created "2016-06-24" @default.
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- W2382893158 date "2007-01-01" @default.
- W2382893158 modified "2023-09-28" @default.
- W2382893158 title "Effects of M-receptor subtype antagonists on pain-inhibition neurons in caudate nucleus" @default.
- W2382893158 hasPublicationYear "2007" @default.
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