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- W2382901487 abstract "【Objective】 To detect the methylation status of RASSF1 gene promoter in primary hepatocellular carcinoma(PHCC) and explore its biomarker role in the diagnosis of PHCC.【Methods】 MSP and RT-PCR were conducted to detect RASSF1 gene promoter's methylation status and its mRNA expression in PHCC and paracancerous tissues respectively.【Results】 51 in 60 PHCC tissues displayed positive methylation status(85.0%) with no mRNA expression,while it was 5% in paracancerous tissues with normal mRNA expression.RASSF1 gene promoter methylation positively correlated with clinical tumor staging and its size,while had nothing to with patients' gender,age and serum AFP levels.【Conclusions】 RASSF1 gene promoter hypermethylation may play a crucial role in the pathogenesis of PHCC,it could be served as a tumor biomarker and provide important molecular clues in the diagnosis and evaluation of PHCC." @default.
- W2382901487 created "2016-06-24" @default.
- W2382901487 creator A5089802003 @default.
- W2382901487 date "2011-01-01" @default.
- W2382901487 modified "2023-09-26" @default.
- W2382901487 title "Methylation status of RASSF1 gene promoter in primary hepatocellular carcinoma and its clinical applications" @default.
- W2382901487 hasPublicationYear "2011" @default.
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